Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Nov 5;1(11):954-6.
doi: 10.18632/aging.100100.

Leptin-dependent co-regulation of bone and energy metabolism

Vijay K Yadav  1 , Gerard Karsenty
Affiliations

Leptin-dependent co-regulation of bone and energy metabolism

Vijay K Yadav et al. Aging (Albany NY). .

Abstract

The adipocyte-derived hormone leptin inhibits appetite and bone mass accrual. To fulfill these two functions leptin requires the integrity of hypothalamic neurons but not the expression of its receptor, ObRb on these neurons. These results suggested that leptin acts first elsewhere in the brain to mediate these functions. However, this neuroanatomical site of leptin action in the brain remained elusive. Recent mouse genetic, electrophysiological and neuroanatomical studies provide evidence that leptin inhibits appetite and bone mass accrual through a two-step pathway: it decreases synthesis and the release by brainstem neurons of serotonin that in turn targets hypothalamic neurons to regulate appetite and bone mass accrual.

Keywords: appetite; bone; energy metabolism; leptin; serotonin.

PubMed Disclaimer

Conflict of interest statement

The authors of this manuscript have no conflict of interest to declare.

Figures

Figure 1.
Figure 1.. Model of the leptin-dependent central control of bone mass, appetite and energy expenditure.
Leptin inhibits release of brainstem-derived serotonin, which favors bone mass accrual and appetite through its action on hypothalamic neurons. Serotonergic neurons are in blue; VMH, ventromedial hypothalamus; ARC, arcuate; VMH is in purple and arcuate is in green.
See this image and copyright information in PMC

References

    1. Rodan GA, Martin TJ. Therapeutic approaches to bone diseases. Science. 2000;289:1508–1514. - PubMed
    1. Lee NK, Sowa H, Hinoi E, Ferron M, Ahn JD, Confavreux C, Dacquin R, Mee PJ, McKee MD, Jung DY, Zhang Z, Kim JK, Mauvais-Jarvis F, Ducy P, Karsenty G. Endocrine regulation of energy metabolism by the skeleton. Cell. 2007;130:456–469. - PMC - PubMed
    1. Zaidi M. Skeletal remodeling in health and disease. Nat Med. 2007;13:791–801. - PubMed
    1. Karsenty G. Convergence between bone and energy homeostases: Leptin regulation of bone mass. Cell Metab. 2006;4:341–348. - PubMed
    1. Felson DT, Zhang Y, Hannan MT, Anderson JJ. Effects of weight and body mass index on bone mineral density in men and women: the Framingham study. J Bone Miner Res. 1993;8:567–573. - PubMed

Publication types

LinkOut - more resources