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. 2009 Dec 9;1(12):1023-7.
doi: 10.18632/aging.100108.

Role of FGF19 induced FGFR4 activation in the regulation of glucose homeostasis

Xinle Wu  1 , Yang Li
Affiliations

Role of FGF19 induced FGFR4 activation in the regulation of glucose homeostasis

Xinle Wu et al. Aging (Albany NY). .

Abstract

FGF19, FGF21, and FGF23 form a unique subfamily of fibroblast growth factors. Because they contain intra-molecular disulfide bonds and show reduced affinity toward heparan sulfate located in the extracellular space, it is thought that, in contrast to other FGFs, they function as endocrine hormones. FGF23 and its co-receptor alphaKlotho are involved in the control of aging, but it is not known if the same holds true for FGF19, which can also signal through alphaKlotho. However, considerable evidence supports a role for FGF19 in controlling various aspects of metabolism. We have recently fully characterized FGF19/FGFR/co-factor interactions and signaling, and in the current manuscript discuss the contribution of the FGF19/FGFR4 axis to bile acid and glucose regulation.

Keywords: FGF19; FGF21; FGF23; aging; diabetes; fibroblast growth factors; insulin; metabolic diseases.

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Conflict of interest statement

The authors of this manuscript are employees of Amgen, Inc.

Figures

Figure 1.
Figure 1.. FGF19 subfamily receptor specificity and functions.
"?" indicates unresolved research areas associated with the physiological significance of the observed FGF/receptor interactions.
See this image and copyright information in PMC

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