Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Oct;9(5):153-7.
doi: 10.4110/in.2009.9.5.153. Epub 2009 Oct 30.

Inhibition of leukocyte adhesion by developmental endothelial locus-1 (del-1)

Eun Young Choi  1
Affiliations

Inhibition of leukocyte adhesion by developmental endothelial locus-1 (del-1)

Eun Young Choi. Immune Netw. 2009 Oct.

Abstract

The leukocyte adhesion to endothelium is pivotal in leukocyte recruitment which takes place during inflammatory, autoimmune and infectious conditions. The interaction between leukocytes and endothelium requires an array of adhesion molecules expressed on leukocytes and endothelial cells, thereby promoting leukocyte recruitment into sites of inflammation and tissue injury. Intervention with the adhesion molecules provides a platform for development of anti-inflammatory therapeutics. This review will focus on developmental endothelial locus-1 (Del-1), an endogenous inhibitor of leukocyte adhesion.

Keywords: Del-1; adhesion molecule; inflammation; leukocyte recruitment.

PubMed Disclaimer

Conflict of interest statement

The authors have no financial conflict of interest.

Figures

Figure 1
Figure 1
A schematic diagram of the process of leukocyte recruitment.
Figure 2
Figure 2
A domain structure of Del-1.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. von Andrian UH, Mackay CR. T-cell function and migration. Two sides of the same coin. N Engl J Med. 2000;343:1020–1034. - PubMed
    1. Luster AD, Alon R, von Andrian UH. Immune cell migration in inflammation: present and future therapeutic targets. Nat Immunol. 2005;6:1182–1190. - PubMed
    1. Ley K, Laudanna C, Cybulsky MI, Nourshargh S. Getting to the site of inflammation: the leukocyte adhesion cascade updated. Nat Rev Immunol. 2007;7:678–689. - PubMed
    1. Zarbock A, Ley K. New insights into leukocyte recruitment by intravital microscopy. Curr Top Microbiol Immunol. 2009;334:129–152. - PubMed
    1. McEver RP, Cummings RD. Perspectives series; cell adhesion in vascular biology. Role of PSGL-1 binding to selectins in leukocyte recruitment. J Clin Invest. 1997;100:485–491. - PMC - PubMed