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. 2009 Oct;9(5):153-7.
doi: 10.4110/in.2009.9.5.153. Epub 2009 Oct 30.

Inhibition of leukocyte adhesion by developmental endothelial locus-1 (del-1)

Eun Young Choi  1
Affiliations

Inhibition of leukocyte adhesion by developmental endothelial locus-1 (del-1)

Eun Young Choi. Immune Netw. 2009 Oct.

Abstract

The leukocyte adhesion to endothelium is pivotal in leukocyte recruitment which takes place during inflammatory, autoimmune and infectious conditions. The interaction between leukocytes and endothelium requires an array of adhesion molecules expressed on leukocytes and endothelial cells, thereby promoting leukocyte recruitment into sites of inflammation and tissue injury. Intervention with the adhesion molecules provides a platform for development of anti-inflammatory therapeutics. This review will focus on developmental endothelial locus-1 (Del-1), an endogenous inhibitor of leukocyte adhesion.

Keywords: Del-1; adhesion molecule; inflammation; leukocyte recruitment.

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Conflict of interest statement

The authors have no financial conflict of interest.

Figures

Figure 1
Figure 1
A schematic diagram of the process of leukocyte recruitment.
Figure 2
Figure 2
A domain structure of Del-1.
See this image and copyright information in PMC

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