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Review
. 2010 Mar;33(1):125-40.
doi: 10.1016/j.psc.2009.10.004.

The genetics of major depression: moving beyond the monoamine hypothesis

Stanley I Shyn  1 , Steven P Hamilton
Affiliations
Review

The genetics of major depression: moving beyond the monoamine hypothesis

Stanley I Shyn et al. Psychiatr Clin North Am. 2010 Mar.

Abstract

Efforts to unlock the biology of major depressive disorder (MDD) are proceeding on multiple fronts. In this article, the authors review the current understanding of epidemiological evidence for a heritable component to MDD risk, as well as recent advances in linkage, candidate gene, and genome-wide association analyses of MDD and related disease subtypes and endophenotypes. While monoamine signaling has preoccupied the bulk of scientific investigation to date, nontraditional gene candidates such as PCLO and GRM7 are now emerging and beginning to change the landscape for future human and animal research on depression.

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