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doi: 10.1016/j.neuron.2010.01.030.
Identification of the synthetic pathway producing the endocannabinoid that mediates the bulk of retrograde signaling in the brain
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- PMID: 20159441
- DOI: 10.1016/j.neuron.2010.01.030
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Identification of the synthetic pathway producing the endocannabinoid that mediates the bulk of retrograde signaling in the brain
Neuron.
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Abstract
Endocannabinoids serve as retrograde messengers that are released by postsynaptic cells to regulate neurotransmitter release from presynaptic boutons. A new study in this issue of Neuron by Tanimura et al. establishes that most endocannabinoid signaling in the brain is a consequence of the calcium-dependent or receptor-driven generation of the retrograde signal 2-arachidonoylglycerol (2-AG) by diacylglycerol lipase alpha (DGLalpha).
Copyright 2010 Elsevier Inc. All rights reserved.
Comment on
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The endocannabinoid 2-arachidonoylglycerol produced by diacylglycerol lipase alpha mediates retrograde suppression of synaptic transmission.Neuron. 2010 Feb 11;65(3):320-7. doi: 10.1016/j.neuron.2010.01.021. Neuron. 2010. PMID: 20159446
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