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Comment
. 2010 Feb 11;65(3):291-2.
doi: 10.1016/j.neuron.2010.01.030.

Identification of the synthetic pathway producing the endocannabinoid that mediates the bulk of retrograde signaling in the brain

Aaron R Best  1 , Wade G Regehr
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Identification of the synthetic pathway producing the endocannabinoid that mediates the bulk of retrograde signaling in the brain

Aaron R Best et al. Neuron. .
Free article

Abstract

Endocannabinoids serve as retrograde messengers that are released by postsynaptic cells to regulate neurotransmitter release from presynaptic boutons. A new study in this issue of Neuron by Tanimura et al. establishes that most endocannabinoid signaling in the brain is a consequence of the calcium-dependent or receptor-driven generation of the retrograde signal 2-arachidonoylglycerol (2-AG) by diacylglycerol lipase alpha (DGLalpha).

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