Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2010 Feb 11;65(3):293-4.
doi: 10.1016/j.neuron.2010.01.028.

Nedd4 branches out

Aaron DiAntonio  1
Affiliations
Comment

Nedd4 branches out

Aaron DiAntonio. Neuron. .

Erratum in

  • Neuron. 2010 Apr 29;66(2):327

Abstract

The branching of dendrites and axons is a key determinant of neural circuit formation. In this issue of Neuron, Kawabe et al. demonstrate that the ubiquitin ligase Nedd4 promotes the branching of developing dendrites by targeting the small G protein Rap2. In a complementary study, Drinjakovic et al. show that Nedd4 promotes the branching of developing axons by ubiquitinating a different target, the phosphatase PTEN.

PubMed Disclaimer

Comment on

References

    1. Campbell DS, Holt CE. Neuron. 2001;32:1013–1026. - PubMed
    1. Collins CA, Wairkar YP, Johnson SL, DiAntonio A. Neuron. 2006;51:57–69. - PubMed
    1. Cosker KE, Eickholt BJ. Biochem Soc Trans. 2007;35:207–210. - PubMed
    1. Drinjakovic J, et al. Neuron. this issue. - PubMed
    1. Kawabe H, et al. Neuron. this issue.

Substances