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Comment
. 2010 Feb 16;18(2):167-8.
doi: 10.1016/j.devcel.2010.02.002.

Telomeric TuRF1 wars

Shireen A Sarraf  1 , J Wade Harper
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Free article
Comment

Telomeric TuRF1 wars

Shireen A Sarraf et al. Dev Cell. .
Free article

Abstract

The TRF1 subunit of the shelterin complex controls telomere length by regulating telomerase access to chromosome ends. Work from Zeng et al. (2010) now reveals in atomic detail how a battle between the SCF(FBX4) ubiquitin ligase and the shelterin component TIN2 controls TRF1 abundance and telomere length homeostasis.

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