Comment
doi: 10.1016/j.ccr.2010.01.012.
Discovery of novel transcriptional and epigenetic targets in APL by global ChIP analyses: Emerging opportunity and challenge
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- PMID: 20159604
- DOI: 10.1016/j.ccr.2010.01.012
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Comment
Discovery of novel transcriptional and epigenetic targets in APL by global ChIP analyses: Emerging opportunity and challenge
Cancer Cell.
.
Free article
Abstract
Identifying transcriptional program(s) deregulated by oncoproteins is key to understanding the molecular basis of the disease. In this issue of Cancer Cell, two studies by Martens et al. and Wang et al. provide global blueprints for transcriptional targets and epigenetic modifications mediated by PML-RARalpha in acute promyelocytic leukemia.
2010 Elsevier Inc. All rights reserved.
Comment on
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PML-RARalpha/RXR Alters the Epigenetic Landscape in Acute Promyelocytic Leukemia.Cancer Cell. 2010 Feb 17;17(2):173-85. doi: 10.1016/j.ccr.2009.12.042. Cancer Cell. 2010. PMID: 20159609
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PML/RARalpha targets promoter regions containing PU.1 consensus and RARE half sites in acute promyelocytic leukemia.Cancer Cell. 2010 Feb 17;17(2):186-97. doi: 10.1016/j.ccr.2009.12.045. Cancer Cell. 2010. PMID: 20159610
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