Association of scavenger receptor class B type I polymorphisms with subclinical atherosclerosis: the Multi-Ethnic Study of Atherosclerosis

Abstract

Background: Little is known about the association of scavenger receptor class B type I (SCARB1) single-nucleotide polymorphisms (SNPs) and subclinical atherosclerosis, particularly in subjects of different racial/ethnic backgrounds. We examined this relationship in the Multi-Ethnic Study of Atherosclerosis.

Methods and results: Forty-three SCARB1-tagging SNPs were genotyped. Baseline examinations included fasting lipids and subclinical atherosclerosis phenotypes (coronary artery calcification, common carotid intimal-medial artery thickness [CCIMT], and internal carotid intimal-medial artery thickness). Examining SNP associations with different subclinical atherosclerosis phenotypes across multiple racial/ethnic groups with adjustment for multiple covariates, we found that the C allele of SNP rs10846744 was associated with higher CCIMT in African American (P=0.03), Chinese (P=0.02), European American (P=0.05), and Hispanic participants (P=0.03) and was strongly associated in pooled analyses (P=0.0002). The results also showed that the association of this SNP with CCIMT was independent of lipids and other well-established cardiovascular risk factors. Stratifying by sex, there seemed to be a strong association of rs10846744 with CCIMT in women, but no genotype-sex interactions were observed.

Conclusions: Variation in SCARB1 at rs10846744 was significantly associated with CCIMT across racial/ethnic groups in Multi-Ethnic Study of Atherosclerosis.

Figure 1

SCARB1 SNP associations with SCA phenotypes (A: CAC; B: CCIMT; C: ICIMT) in MESA participants under an additive genetic model (model 1). Empirically-estimated p-values for AFA are shown with gray triangles, CHN with gray diamonds, EUA with black squares, and HIS with black circles. The light grey line demarcates P=0.05.

Figure 1

SCARB1 SNP associations with SCA phenotypes (A: CAC; B: CCIMT; C: ICIMT) in MESA participants under an additive genetic model (model 1). Empirically-estimated p-values for AFA are shown with gray triangles, CHN with gray diamonds, EUA with black squares, and HIS with black circles. The light grey line demarcates P=0.05.

Figure 1

SCARB1 SNP associations with SCA phenotypes (A: CAC; B: CCIMT; C: ICIMT) in MESA participants under an additive genetic model (model 1). Empirically-estimated p-values for AFA are shown with gray triangles, CHN with gray diamonds, EUA with black squares, and HIS with black circles. The light grey line demarcates P=0.05.