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Multicenter Study
. 2010 Mar 16;102(6):952-6.
doi: 10.1038/sj.bjc.6605547. Epub 2010 Feb 16.

The prognostic value of plasma fibrinogen levels in patients with endometrial cancer: a multi-centre trial

V Seebacher  1 , S Polterauer, C Grimm, H Husslein, H Leipold, K Hefler-Frischmuth, C Tempfer, A Reinthaller, L Hefler
Affiliations
Multicenter Study

The prognostic value of plasma fibrinogen levels in patients with endometrial cancer: a multi-centre trial

V Seebacher et al. Br J Cancer. .

Abstract

Background: To analyse the correlation between pre-treatment plasma fibrinogen levels and clinical-pathological parameters in patients with endometrial cancer and to assess the value of plasma fibrinogen as a prognostic parameter.

Methods: Within a retrospective multi-centre study, the records of 436 patients with endometrial cancer were reviewed and pre-treatment plasma fibrinogen levels were correlated with clinical-pathological parameters and patients' survival.

Results: The mean (s.d.) pre-treatment plasma fibrinogen level was 388.9 (102.4) mg per 100 ml. Higher plasma fibrinogen levels were associated with advanced tumour stage (FIGO I vs II vs III and IV, P=0.002), unfavourable histological subtype (endometrioid vs non-endometrioid histology, P=0.03), and higher patients' age (< or =67 years vs >67 years, P=0.04), but not with higher histological grade (G1 vs G2 vs G3, P=0.2). In a multivariate analysis, tumour stage (P<0.001 and P<0.001), histological grade (P=0.009 and P=0.002), patients' age (P=0.001 and P<0.001), and pre-treatment plasma fibrinogen levels (P=0.04 and P=0.02) were associated with disease-free and overall survival, respectively.

Conclusion: Plasma fibrinogen levels can be used as an independent prognostic parameter for the disease-free and overall survival of patients with endometrial cancer.

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Figures

Figure 1
Figure 1
Kaplan–Meier curves for disease-free survival broken down by the mean plasma fibrinogen level.
Figure 2
Figure 2
Kaplan–Meier curves for overall survival broken down by the mean plasma fibrinogen level.
See this image and copyright information in PMC

References

    1. Andreasen PA, Egelund R, Petersen HH (2000) The plasminogen activation system in tumor growth, invasion, and metastasis. Cell Mol Life Sci 57: 25–40 - PMC - PubMed
    1. Balkwill F, Mantovani A (2001) Inflammation and cancer: back to Virchow? Lancet 357: 539–545 - PubMed
    1. Bardos H, Molnar P, Csecsei G, Adany R (1996) Fibrin deposition in primary and metastatic human brain tumours. Blood Coagul Fibrinolysis 7: 536–548 - PubMed
    1. Biggerstaff JP, Weidow B, Dexheimer J, Warnes G, Vidosh J, Patel S, Newman M, Patel P (2008) Soluble fibrin inhibits lymphocyte adherence and cytotoxicity against tumor cells: implications for cancer metastasis and immunotherapy. Clin Appl Thromb Hemost 14: 193–202 - PubMed
    1. Biggerstaff JP, Weidow B, Vidosh J, Dexheimer J, Patel S, Patel P (2006) Soluble fibrin inhibits monocyte adherence and cytotoxicity against tumor cells: implications for cancer metastasis. Thromb J 4: 12. - PMC - PubMed