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. 2009 Aug 1;3(4):363-383.
doi: 10.2217/bmm.09.30.

Molecular biomarkers in stroke diagnosis and prognosis

Matthew B Maas  1 , Karen L Furie
Affiliations

Molecular biomarkers in stroke diagnosis and prognosis

Matthew B Maas et al. Biomark Med. .

Abstract

Serum biomarkers related to the cascade of inflammatory, hemostatic, glial and neuronal perturbations have been identifed to diagnose and characterize intracerebral hemorrhage and cerebral ischemia. Interpretation of most markers is confounded by their latent rise, blood-brain barrier effects, the heterogeneity of etiologies and the wide range of normal values, limiting their application for early diagnosis, lesion size estimation and long-term outcome prediction. Certain hemostatic and inflammatory constituents have been found to predict response to thrombolysis and worsening due to infarct progression and secondary hemorrhage, offering a potential role for improved treatment selection and individualization of therapy. Biomarkers will become increasingly relevant for developing targets for neuroprotective therapies, monitoring response to treatment and as surrogate end points for treatment trials.

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References

    1. Rosamond W, Flegal K, Furie K, et al. Heart disease and stroke statistics — 2008 update: a report from the american heart association statistics committee and stroke statistics subcommittee. Circulation. 2008;117(4):e25–e146. - PubMed
    1. Goldstein LB, Adams R, Alberts MJ, et al. Primary prevention of ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council: cosponsored by the Atherosclerotic Peripheral Vascular Disease Interdisciplinary Working Group; Cardiovascular Nursing Council; Clinical Cardiology Council; Nutrition, Physical Activity, and Metabolism Council; and the Quality of Care and Outcomes Research Interdisciplinary Working Group: the American Academy of Neurology affrms the value of this guideline. Stroke. 2006;37(6):1583–1633. - PubMed
    1. Sacco RL, Adams R, Albers G, et al. Guidelines for prevention of stroke in patients with ischemic stroke or transient ischemic attack: a statement for healthcare professionals from the American Heart Association/American Stroke Association Council on Stroke: co-sponsored by the Council on Cardiovascular Radiology and Intervention: the American Academy of Neurology affrms the value of this guideline. Stroke. 2006;37(2):577–617. - PubMed
    1. Adams RJ, Albers G, Alberts MJ, et al. Update to the AHA/ASA recommendations for the prevention of stroke in patients with stroke and transient ischemic attack. Stroke. 2008;39(5):1647–1652. - PMC - PubMed
    1. Alpert JS, Thygesen K, Antman E, Bassand JP. Myocardial infarction redefined — a consensus document of the joint european society of Cardiology/ American college of cardiology committee for the redefinition of myocardial infarction. J. Am. Coll. Cardiol. 2000;36(3):959–969. - PubMed