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. 2009 May 1;4(3):295-304.
doi: 10.2217/fnl.09.12.

Novel approaches to imaging epilepsy by MRI

Hoby Hetherington  1
Affiliations

Novel approaches to imaging epilepsy by MRI

Hoby Hetherington. Future Neurol. .

Abstract

As the concept of a network of injury has emerged in the treatment of epilepsy, the importance of evaluating that network noninvasively has also grown. Recently, studies utilizing magnetic resonance spectroscopic imaging, manganese-enhanced MRI and functional (f)MRI measures of resting state connectivity have demonstrated their ability to detect injury and dysfunction in cerebral networks involved in the propagation of seizures. The ability to noninvasively detect neuronal injury and dysfunction throughout cerebral networks should improve surgical planning, provide guidance for placement of devices that target network propagation and provide insights into the mechanisms of recurrence following resective surgery.

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Figures

Figure 1
Figure 1. 1H magnetic resonance spectra from a column along the hippocampus from a control subject
The labeled resonances are water, Cr, MI, Ch and NAA. The locations of the magnetic resonance spectra are indicated by the red box overlaid on the anatomical image. Ch: Choline; Cr: Creatine; MI: Myoinositol; NAA: N-acetylaspartate.
Figure 2
Figure 2. 1H magnetic resonance spectra from a patient with temporal lobe epilepsy
Note the decreases in NAA/Cr in the ipsilateral hippocampus are greater than that seen in the contralateral hippocampus, and that seen in controls (FIGURE 1). The spectra are overlaid on the anatomical image. Ch: Choline; Contra: Contralateral; Cr: Creatine; Ipsi: Ipsilateral; NAA: N-acetyl aspartate; MI: Myoinositol.
Figure 3
Figure 3. 31P spectrum from a control subject displaying the resonance of inorganic phosphate, phosphocreatine & ATP
Shown below is an image from a patient with temporal lobe epilepsy showing the decrease in PCr/ATP from the ipsilateral hippocampus. Contra: Contralateral; Ipsi: Ipsilateral; PCr: Phosphocreatine; Pi: Phosphatidylinositol.
Figure 4
Figure 4
Network of correlations (Pearson) of N-acetylaspartate/creatine between the hippocampus, anterior & posterior hippocampus and basal ganglia in patients with temporal lobe epilepsy.
See this image and copyright information in PMC

References

    1. Margerison JH, Corsellis JAN. Epilepsy and the temporal lobes. Brain. 1968;91:499–531. - PubMed
    1. Blumenfeld H, McNally KA, Vanderhill SD, et al. Positive and negative network correlations in temporal lobe epilepsy. Cereb. Cortex. 2004;14(8):892–902. - PubMed
    1. Labate A, Cerasa A, Gambardella A, Aguglia U, Quattrone A. Hippocampal and thalamic atrophy in mild temporal lobe epilepsy: a VBM study. Neurology. 2008;71(14):1094–1101. - PubMed
    1. Riederer F, Lanzenberger R, Kaya M, et al. Network atrophy in temporal lobe epilepsy: a voxel-based morphometry study. Neurology. 2008;71(6):419–425. - PubMed
    1. Gong G, Concha L, Beaulieu C, Gross DW. Thalamic diffusion and volumetry in temporal lobe epilepsy with and without mesial temporal sclerosis. Epilepsy Res. 2008;80(2–3):184–193. - PubMed

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