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. 2009 Apr 18;65(16):3270-3280.
doi: 10.1016/j.tet.2008.11.086.

Strategic use of nickel(0)-catalyzed enyne-epoxide reductive coupling towards the synthesis of (-)-cyatha-3,12-diene

Brian A Sparling  1 , Graham L Simpson, Timothy F Jamison
Affiliations

Strategic use of nickel(0)-catalyzed enyne-epoxide reductive coupling towards the synthesis of (-)-cyatha-3,12-diene

Brian A Sparling et al. Tetrahedron. .

Abstract

Various situations are explored in which the nickel(0)-catalyzed enyne-epoxide reductive coupling was utilized to access key intermediates towards the total synthesis of (-)-cyatha-3,12-diene (1). Enantioenriched 3,5-dien-1-ols with a variety of functionality were obtained in a straightforward manner from easily accessible 1,3-enynes and terminal epoxides.

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