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. 2009 Sep 1:46:9.11.1-9.11.21.
doi: 10.1002/0471141755.ph0911s46.

Natural Products as a Foundation for Drug Discovery

John A Beutler  1
Affiliations

Natural Products as a Foundation for Drug Discovery

John A Beutler. Curr Protoc Pharmacol. .

Abstract

Natural products have contributed to the development of many drugs for diverse indications. While most U.S. pharmaceutical companies have reduced or eliminated their in-house natural product groups, new paradigms and new enterprises have evolved to carry on a role for natural products in the pharmaceutical industry. Many of the reasons for the decline in popularity of natural products are being addressed by the development of new techniques for screening and production. This overview aims to inform pharmacologists of current strategies and techniques that make natural products a viable strategic choice for inclusion in drug discovery programs.

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Figures

Figure 1
Figure 1
Extremes of complexity in natural product structures: a) Palytoxin and b) pinene.
Figure 1
Figure 1
Extremes of complexity in natural product structures: a) Palytoxin and b) pinene.
Figure 2
Figure 2
Bryostatin 1 and a bryolog (Wender et al., 2008).
Figure 2
Figure 2
Bryostatin 1 and a bryolog (Wender et al., 2008).
Figure 3
Figure 3
Halichondrin B and its simplified analog eribulin (Newman, 2007).
Figure 3
Figure 3
Halichondrin B and its simplified analog eribulin (Newman, 2007).
Figure 4
Figure 4
Structures of some common nuisance compounds. a. A common condensed tannin, proanthocyanin C1. b. A hydolyzable tannin. c. A phorbol ester, phorbol 12-tigliate 13-decanoate. d. A saponin, ginsenoside Rb2. e. General repeating structure of a marine anionic polysaccharide. f. General repeating structure of a cationic polymeric alkylpyridine, halitoxin.
Figure 4
Figure 4
Structures of some common nuisance compounds. a. A common condensed tannin, proanthocyanin C1. b. A hydolyzable tannin. c. A phorbol ester, phorbol 12-tigliate 13-decanoate. d. A saponin, ginsenoside Rb2. e. General repeating structure of a marine anionic polysaccharide. f. General repeating structure of a cationic polymeric alkylpyridine, halitoxin.
Figure 4
Figure 4
Structures of some common nuisance compounds. a. A common condensed tannin, proanthocyanin C1. b. A hydolyzable tannin. c. A phorbol ester, phorbol 12-tigliate 13-decanoate. d. A saponin, ginsenoside Rb2. e. General repeating structure of a marine anionic polysaccharide. f. General repeating structure of a cationic polymeric alkylpyridine, halitoxin.
Figure 4
Figure 4
Structures of some common nuisance compounds. a. A common condensed tannin, proanthocyanin C1. b. A hydolyzable tannin. c. A phorbol ester, phorbol 12-tigliate 13-decanoate. d. A saponin, ginsenoside Rb2. e. General repeating structure of a marine anionic polysaccharide. f. General repeating structure of a cationic polymeric alkylpyridine, halitoxin.
Figure 4
Figure 4
Structures of some common nuisance compounds. a. A common condensed tannin, proanthocyanin C1. b. A hydolyzable tannin. c. A phorbol ester, phorbol 12-tigliate 13-decanoate. d. A saponin, ginsenoside Rb2. e. General repeating structure of a marine anionic polysaccharide. f. General repeating structure of a cationic polymeric alkylpyridine, halitoxin.
Figure 4
Figure 4
Structures of some common nuisance compounds. a. A common condensed tannin, proanthocyanin C1. b. A hydolyzable tannin. c. A phorbol ester, phorbol 12-tigliate 13-decanoate. d. A saponin, ginsenoside Rb2. e. General repeating structure of a marine anionic polysaccharide. f. General repeating structure of a cationic polymeric alkylpyridine, halitoxin.
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