Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2007 Feb 16;4(3):362-71.
doi: 10.4314/ajtcam.v4i3.31230.

Antihyperglycemic effects of separate and composite extract of root of Musa paradisiaca and leaf of Coccinia indica in streptozotocin-induced diabetic male albino rat

Chhanda Mallick  1 , Kausik Chatterjee, Mehuli Guhabiswas, Debidas Ghosh
Affiliations

Antihyperglycemic effects of separate and composite extract of root of Musa paradisiaca and leaf of Coccinia indica in streptozotocin-induced diabetic male albino rat

Chhanda Mallick et al. Afr J Tradit Complement Altern Med. .

Abstract

We evaluated the antihyperglycaemic properties of aqueous-methanolic (40:60) extract of root of Musa paradisiaca and leaf of Coccinia indica in separate as well as in composite manner by conducting experiment on streptozotocin-induced diabetic rats. We measured food and water intake ability, the fasting blood glucose level, glucose tolerance, activities of important carbohydrate metabolic enzymes like glucose-6-phosphatase, glucose-6-phosphate dehydrogenase, hexokinase in liver along with quantification of glycogen in liver and in skeletal muscle and serum insulin level. We noted that after treatment of aqueous methanolic extract of above plant parts in separate as well as in composite manner at a concentration of 80 mg/100 g body weight/day to streptozotocin-induced diabetic rat resulted in a significant remedial effect on blood glucose level as well as carbohydrate metabolic enzymes and the quantity of liver and skeletal muscle glycogen. Serum insulin level that was diminished in streptozotocin-induced diabetic rat recovered significantly after the co-administration of extract of above plant parts. All the above parameters showed a more potent remedial effect after composite extract treatment with respect to separate treatment and none of the extract has any general metabolic toxicity induction.

Keywords: Coccinia indica; Diabetes; Glycaemic index; Insulin; Musa paradisiaca.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Effect of aqueous-methanolic extract of root of M. paradisiaca and leaf of C. indica on serum insulin and glycogen content in liver and muscle. Data are expressed as Mean ±SEM, n=8. ANOVA followed by multiple comparison two tail ‘t’ test. Values with * or ** on bar in case of specific parameter differ from others significantly at (p<0.05)
Figure 2
Figure 2
Effect of aqueous-methanolic extract of root of M. paradisiaca and leaf of C. indica on glucose-6-phosphatase and glucose-6-phosphate dehydrogenase and hexokinase activities in liver. Data are expressed as Mean ±SEM, n = 8. ANOVA followed by multiple comparison two tail ‘t’ test. Values with * or ** on each bar in case of specific parameter differ from others significantly at (p<0.05).
Figure 3
Figure 3
Effect of separate and composite methanolic extract of root of M. paradisiaca and leaf of C indica on GOT and GPT levels. Data are expressed as Mean ±SEM, n=8. ANOVA followed by multiple comparison two tail ‘t’ test. Values with * or ** on each bar in case of specific parameter differ from others significantly at (p<0.05).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Akther M H, Mathur M, Vhide N K. Skin and liver toxicity in experimental Lantana camara poisoning in albino rats. Ind J Physiol Pharmacol. 1990;34:13–16. - PubMed
    1. Brugi W, Briner M, Fraken N, Kessler ACH. One step sandwich enzyme immuno assay for insulin using monoclonal antibodies. Clin Biochem. 1988;21:311–314. - PubMed
    1. Can A, Akev N, Ozsoy N, Bolkent S, Arda BP, Yanardag R, Okyar A. Effect of Aloevera leaf gel and pulp extract on the liver in type II diabetic rat models. Biol Pharm Bull. 2004;27:694–698. - PubMed
    1. Chopra RN, Chopra IC, Handa KL, Kapur LD. Medicinal plant in diabetes. In: Gupta P, editor. Indigenous Drug of India. 2nd ed. Calcutta, India: U.N. Dhar & Sons Ltd; 1958. pp. 314–316.
    1. Chou AC, Wilson JE. Carbohydrate metabolism. In: Wood WA, editor. Methods in Enzymol. XIII. New York: Academic Press; 1975. pp. 20–21. - PubMed

LinkOut - more resources