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. 2007 Oct 27;5(1):46-50.

In vivo screening of antimalarial activity of Acacia mellifera (Benth) (Leguminosae) on Plasmodium berghei in mice

Charles Mutai  1 , Geoffrey Rukunga, Constatinos Vagias, Vassilios Roussis
Affiliations

In vivo screening of antimalarial activity of Acacia mellifera (Benth) (Leguminosae) on Plasmodium berghei in mice

Charles Mutai et al. Afr J Tradit Complement Altern Med. .

Abstract

The activities of total extracts and lupane triterpenes, isolated from the stem bark of Acacia mellifera, were evaluated against Plasmodium berghei strain ANKA in a female Swiss mouse model. Five isolated compounds and the crude extracts were evaluated for antimalarial activity and Quinine hydrochloride was used as a positive control. Only betulin and the methanolic extract produced considerable antimalarial activity in mice infected with P. berghei parasites. This study demonstrated the presence of bioactive agents in Acacia mellifera.

Keywords: Acacia mellifera; Antimalarial activity; lupane triterpenes; mice.

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Figures

Figure 1
Figure 1
Isolated compounds
Figure 2
Figure 2
Progression of parasitemia with time after treatment with total extracts
Figure 3
Figure 3
Progression of parasitemia with time after treatment with pure compounds
See this image and copyright information in PMC

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