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. 2006 Nov 13;4(2):219-25.
doi: 10.4314/ajtcam.v4i2.31211.

Brine shrimp toxicity evaluation of some Tanzanian plants used traditionally for the treatment of fungal infections

Mainen J Moshi  1 , Carolien J P van den Beukel, Omar J M Hamza, Zakaria H Mbwambo, Ramadhani O S Nondo, Pax J Masimba, Mecky I N Matee, Modest C Kapingu, Frans Mikx, Paul E Verweij, André J A M van der Ven
Affiliations

Brine shrimp toxicity evaluation of some Tanzanian plants used traditionally for the treatment of fungal infections

Mainen J Moshi et al. Afr J Tradit Complement Altern Med. .

Abstract

Plants which are used by traditional healers in Tanzania have been evaluated to obtain preliminary data of their toxicity using the brine shrimps test. The results indicate that 9 out of 44 plant species whose extracts were tested exhibited high toxicity with LC(50) values below 20 microg/ml. These include Aloe lateritia Engl. (Aloaceae) [19.1 microg/ml], Cassia abbreviata Oliv. (Caesalpiniaceae) [12.7 microg/ml], Croton scheffleri Pax (Euphorbiaceae) [13.7 microg/ml], Hymenodactyon parvifolium Brig (Rubiaceae) [13.4 microg/ml], Kigelia Africana L. (Bignoniaceae) [7.2 microg/ml], and Ocimum suave Oliv. (Labiatae) [16.7 microg/ml]. Twelve plants gave LC(50) values between 21 and 50 microg/ml, 11 plants gave LC(50) values between 50 and 100 microg/ml, and 18 plants gave LC(50) values greater than 100 microg/ml.

Keywords: Brine shrimp test; Toxicity evaluation; Traditional antifungal plants.

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References

    1. AIDS Analysis Africa. 1996 Feb;:12–13. - PubMed
    1. Bastert J, Schaller M, Korting HC, Evans EG. Current and future approaches to antimycotic treatment in the era of resistant fungi and immunocompromised hosts. Intl J Antimicr Agents. 2001;17:81–91. - PubMed
    1. Debruyne D. Clinical pharmacokinetics of fluconazole in superficial and systemic mycoses. Clin Pharmacok. 1997;33:52–77. - PubMed
    1. Hamza OJM, van den Beukel CJP, Mecky IN, Matee MIN, Moshi MJ, Mikx F, Haji O, Selemani HO, Mbwambo ZH, Van der Ven AJAM, Verweij PE. Antifungal activity of some Tanzanian plants used traditionally for the treatment of fungal infections. J Ethnopharmacol. 2006 May 22; [Epub ahead of print] - PubMed
    1. Kilima PM, Ostermayer I, Shija M, Wolff MM, Evans PJ. Drug utilization, prescribing habits and patients in City Council Health Facilities, Dar es Salaam, Tanzania. Basel: DUHP, Swiss Tropical Institute; 1993. p. 19.

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