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. 2010 Feb;24(2):265-85.
doi: 10.1080/13854040903482830.

Neurocognitive functioning in HIV-1 infection: effects of cerebrovascular risk factors and age

Jessica Foley  1 , Mark Ettenhofer, Matthew J Wright, Iraj Siddiqi, Melissa Choi, April D Thames, Karen Mason, Steven Castellon, Charles H Hinkin
Affiliations

Neurocognitive functioning in HIV-1 infection: effects of cerebrovascular risk factors and age

Jessica Foley et al. Clin Neuropsychol. 2010 Feb.

Abstract

This study examined the interactive effects of cerebrovascular risks, advancing age, and HIV infection on neurocognition, and explored whether pharmacological treatment of cerebrovascular risk factors attenuated neurocognitive dysfunction. Participants included 98 HIV-seropositive adults (cerebrovascular risk: 23.5%; age > 50: 27.6%). Cerebrovascular risk was associated with slower processing speed even after controlling for age effects (b = -2.071; p =.04), and the interaction of age and cerebrovascular risk was associated with poorer verbal fluency (b = 1.276, p =.002). Participants with pharmacologically untreated cerebrovascular risk demonstrated reduced processing speed, learning/memory, and executive functioning relative to those on medication. Poor cerebrovascular health confers significant risk for HIV+ individuals, and this effect may be of greater consequence than advancing age. The cognitive impact of risk appears to be more pronounced in the absence of adequate pharmacological treatment.

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Figures

Figure 1
Figure 1
Cognitive performances for cerebrovascular at-risk subgroups and seropositive controls. Note: Standard Error of the Mean noted above each bar.
See this image and copyright information in PMC

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