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. 2010 Feb;51(1):48-53.
doi: 10.3325/cmj.2010.51.48.

Association of nephrolithiasis and gene for glucose transporter type 9 (SLC2A9): study of 145 patients

Ozren Polasek  1 , Grgo Gunjaca, Ivana Kolcić, Lina Zgaga, Snjezana Dzijan, Robert Smolić, Martina Smolić, Jasminka Milas-Ahić, Vatroslav Serić, Josip Galić, Sandra Tucak-Zorić, Antun Tucak, Igor Rudan, Gordan Lauc
Affiliations

Association of nephrolithiasis and gene for glucose transporter type 9 (SLC2A9): study of 145 patients

Ozren Polasek et al. Croat Med J. 2010 Feb.

Abstract

Aim: To investigate the association of nephrolithiasis and solute carrier family 2, facilitated glucose transporter, member 9 (SLC2A9), also known as glucose transporter type 9, Glut9.

Methods: A total of 145 participants were recruited in the period April-October 2008 from the Department of Mineral Research of the Medical School Osijek, Osijek, Croatia; 58 (40%) had confirmed nephrolithiasis and 87 (60%) were asymptomatic. Four single nucleotide polymorphisms (SNP) from the SLC2A9 gene were genotyped in both groups (rs733175, rs6449213, rs1014290, and rs737267).

Results: There was a weak but significant association of all 4 SNPs and nephrolithiasis (P=0.029 for rs733175; P=0.006 for rs6449213; P=0.020 for rs1014290, and P=0.011 for rs737267). Logistic regression in an age- and sex-adjusted model suggested that genotype C/T for rs6449213 had odds ratio for nephrolithiasis of 2.89 (95% confidence interval 1.13-7.40). This SNP explained a total of 4.4% of nephrolithiasis variance.

Conclusion: Development of nephrolithiasis may be associated with SLC2A9 gene. Further studies are needed to clarify the role of SLC2A9 gene as a link between uric acid and nephrolithiasis.

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