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. 2010 Mar 17;132(10):3262-3.
doi: 10.1021/ja100101n.

Chiral silver amide-catalyzed enantioselective [3 + 2] cycloaddition of alpha-aminophosphonates with olefins

Yasuhiro Yamashita  1 , Xun-Xiang Guo, Ryuta Takashita, Shū Kobayashi
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Chiral silver amide-catalyzed enantioselective [3 + 2] cycloaddition of alpha-aminophosphonates with olefins

Yasuhiro Yamashita et al. J Am Chem Soc. .

Abstract

The first catalytic asymmetric [3 + 2] cycloadditions of Schiff bases of alpha-aminophosphonates with olefins have been developed. Chiral silver amide complexes bearing (R)-DTBM-SEGPHOS worked well as catalysts for the first time, and proline phosphonic analogues were obtained in high yields with excellent exo- and enantioselectivities.

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