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. 1978 Jan;76(1):1-11.
doi: 10.1083/jcb.76.1.1.

Sites of lipoprotein particles in normal rat hepatocytes

P M Novikoff, A Yam

Sites of lipoprotein particles in normal rat hepatocytes

P M Novikoff et al. J Cell Biol. 1978 Jan.

Abstract

Very low density lipoprotein (VLDL) particles are packaged by the Golgi apparatus into vacuoles which move to the plasma membrane and empty the particles into the space of Disse, via exocytosis. Traditionally, all lipoprotein-containing cisternae and vacuoles are thought to be parts of this pathway. Observations reported here demonstrate that there is a second population of lipoprotein-containing cisternae and vacuoles. This population is part of GERL, an organelle we consider to be a specialized hydrolase-rich region of the endoplasmic reticulum (ER). To our knowledge, this is the first systematic study of GERL in normal rat hepatocytes.

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References

    1. J Biol Chem. 1976 Aug 25;251(16):4914-21 - PubMed
    1. Adv Lipid Res. 1975;13:1-89 - PubMed
    1. J Cell Biol. 1976 May;69(2):241-63 - PubMed
    1. Proc Natl Acad Sci U S A. 1975 Nov;72(11):4501-5 - PubMed
    1. Lab Invest. 1974 Jun;30(6):732-50 - PubMed

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