Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010;20(1):37-41.
doi: 10.3233/JAD-2010-1345.

Lack of implication for CALHM1 P86L common variation in Italian patients with early and late onset Alzheimer's disease

Benedetta Nacmias  1 , Andrea Tedde, Silvia Bagnoli, Ersilia Lucenteforte, Elena Cellini, Irene Piaceri, Bianca Maria Guarnieri, Valentina Bessi, Laura Bracco, Sandro Sorbi
Affiliations

Lack of implication for CALHM1 P86L common variation in Italian patients with early and late onset Alzheimer's disease

Benedetta Nacmias et al. J Alzheimers Dis. 2010.

Abstract

A recent study identified a polymorphism (Pro86Leu) in the Calcium homeostasis modulator 1 (CALHM1) gene whose minor Leucine allele showed a higher frequency in Alzheimer's disease (AD) patients compared to controls (29% in AD and 22% in controls). Further studies provided conflicting results in different ethnic groups. In order to assess the involvement of the CALHM1 genetic variant on the risk of developing AD, we analyzed the genotype and allele distributions of the Pro86Leu polymorphism in 758 Italian subjects. Our results did not confirm an association between the CALHM1 variation and AD, thus suggesting a genetic heterogeneity among the various populations.

PubMed Disclaimer

Publication types

LinkOut - more resources