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. 2009 Apr;13(1):23-7.
doi: 10.4103/0019-5278.50720.

Assessment of erythrocyte acetylcholine esterase activities in painters

Mohd Imran Khan  1 , Abbas Ali Mahdi, Najmul Islam, Subodh Kumar Rastogi, M P S Negi
Affiliations

Assessment of erythrocyte acetylcholine esterase activities in painters

Mohd Imran Khan et al. Indian J Occup Environ Med. 2009 Apr.

Abstract

Thirty-five male painters in the age group of 20-50 years occupationally engaged in domestic and commercial painting for 5-12 years having blood lead levels (BLL) </=40 mug/dl were subjected to the determination of acetyl choline esterase (AChE) levels both in plasma and red blood cell (RBC) lysate. BLL were determined using a graphite furnace atomic absorption spectrometer. The results showed that BLL were 7.7 times higher in the painters as compared with that of the control group. Significant decreases in RBC and plasma AChE were observed in the exposed group in comparison with controls. RBC and plasma AChE showed a decrease of 18.4% and 18%, respectively, in the exposed group. The findings also indicated a significant negative correlation of both RBC and plasma AChE activities with BLL. The marked reduction observed in both RBC and plasma AChE activity may account for disruption of cholinergic function and result in neurotoxicity among the painters.

Keywords: AChE in red blood cell and plasma; blood lead; painters.

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Conflict of interest statement

Conflict of Interest: Nil

Figures

Figure 1
Figure 1
(A) Best-fit regression between blood Pb and plasma AChE (B) Best-fit regression between blood Pb and RBC AChE
See this image and copyright information in PMC

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