Selectively nonselective kinase inhibition: striking the right balance
- PMID: 20166671
- DOI: 10.1021/jm901132v
Selectively nonselective kinase inhibition: striking the right balance
Similar articles
-
Discovery and development of aurora kinase inhibitors as anticancer agents.J Med Chem. 2009 May 14;52(9):2629-51. doi: 10.1021/jm8012129. J Med Chem. 2009. PMID: 19320489 Review. No abstract available.
-
Structure-based design and synthesis of novel macrocyclic pyrazolo[1,5-a] [1,3,5]triazine compounds as potent inhibitors of protein kinase CK2 and their anticancer activities.Bioorg Med Chem Lett. 2008 Jan 15;18(2):619-23. doi: 10.1016/j.bmcl.2007.11.074. Epub 2007 Nov 28. Bioorg Med Chem Lett. 2008. PMID: 18055206
-
Synthesis and structure-activity relationship of 3,4'-bispyridinylethylenes: discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancer.Bioorg Med Chem Lett. 2006 Apr 1;16(7):2000-7. doi: 10.1016/j.bmcl.2005.12.065. Epub 2006 Jan 18. Bioorg Med Chem Lett. 2006. PMID: 16413780
-
Structural biology contributions to tyrosine kinase drug discovery.Curr Opin Cell Biol. 2009 Apr;21(2):280-7. doi: 10.1016/j.ceb.2009.01.012. Epub 2009 Feb 7. Curr Opin Cell Biol. 2009. PMID: 19208462 Review.
-
Structure-based discovery and optimization of potential cancer therapeutics targeting the cell cycle.IDrugs. 2006 Apr;9(4):273-8. IDrugs. 2006. PMID: 16596481 Review.
Cited by
-
Fine-tuning of a generative neural network for designing multi-target compounds.J Comput Aided Mol Des. 2022 May;36(5):363-371. doi: 10.1007/s10822-021-00392-8. Epub 2021 May 28. J Comput Aided Mol Des. 2022. PMID: 34046745 Free PMC article.
-
Optimization of substituted 6-salicyl-4-anilinoquinazoline derivatives as dual EGFR/HER2 tyrosine kinase inhibitors.PLoS One. 2013 Aug 1;8(8):e69427. doi: 10.1371/journal.pone.0069427. Print 2013. PLoS One. 2013. PMID: 23936329 Free PMC article.
-
Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors.J Vis Exp. 2015 Oct 26;(105):e52441. doi: 10.3791/52441. J Vis Exp. 2015. PMID: 26554946 Free PMC article.
-
A ranking method for the concurrent learning of compounds with various activity profiles.J Cheminform. 2015 Jan 16;7(1):2. doi: 10.1186/s13321-014-0050-6. eCollection 2015. J Cheminform. 2015. PMID: 25643067 Free PMC article.
-
Modulation of insulin-like growth factor-1 receptor and its signaling network for the treatment of cancer: current status and future perspectives.Oncol Rev. 2013 Apr 22;7(1):e3. doi: 10.4081/oncol.2013.e3. eCollection 2013 Apr 22. Oncol Rev. 2013. PMID: 25992224 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Chemical Information