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. 2010 Mar 19;12(6):1224-7.
doi: 10.1021/ol1000796.

Regioselective reactions of highly substituted arynes

Pamela M Tadross  1 , Christopher D Gilmore, Pradeep Bugga, Scott C Virgil, Brian M Stoltz
Affiliations

Regioselective reactions of highly substituted arynes

Pamela M Tadross et al. Org Lett. .

Abstract

The fully regioselective reactivity of four new highly substituted silyl aryl triflate aryne precursors in aryne acyl-alkylation, acyl-alkylation/condensation, and heteroannulation reactions is reported. The application of these more complex arynes provides access to diverse natural product scaffolds and obviates late-stage functionalization of aromatic rings.

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