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. 2010 Apr 23;73(4):720-3.
doi: 10.1021/np900539j.

Agelastatin E, agelastatin F, and benzosceptrin C from the marine sponge Agelas dendromorpha

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Agelastatin E, agelastatin F, and benzosceptrin C from the marine sponge Agelas dendromorpha

Supriya Tilvi et al. J Nat Prod. .

Abstract

The study of the n-butanol extract of the New Caledonian sponge Agelas dendromorpha led to the isolation and identification of three new pyrrole-2-aminoimidazole (P-2-AI) alkaloids, named agelastatins E (3) and F (4) and benzosceptrin C (5), together with 10 known metabolites, agelastatin A (1), agelastatin D (2), sceptrin (6), manzacidin A, tauroacidin A, taurodispacamide A, nortopsentin D, thymine, longamide, and 4,5-dibromopyrrole-2-carboxamide. Their structures were assigned by spectroscopic data interpretation. All the compounds were tested for cytotoxic activity.

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