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. 2010 Feb 18:5:13.
doi: 10.1186/1746-1596-5-13.

The relationship of cerb B 2 expression with estrogen receptor and progesterone receptor and prognostic parameters in endometrial carcinomas

Aylin Ege Gul  1 , Sevinc Hallac Keser, Nagehan Ozdemir Barisik, Nilufer Onak Kandemir, Caglar Cakir, Sibel Sensu, Nimet Karadayi
Affiliations

The relationship of cerb B 2 expression with estrogen receptor and progesterone receptor and prognostic parameters in endometrial carcinomas

Aylin Ege Gul et al. Diagn Pathol. .

Abstract

Background: Endometrial carcinoma (EC) is the most common malignancy of the female genital tract. Gene alterations and overexpression of various oncogenes are important in tumor development. The human HER 2 neu (c-erbB-2) gene product is a transmembrane receptor with an intracellular tyrosine kinase that plays an important role in coordinating the endometrial growth factor receptor signaling network. The aim of this study was to investigate the expression of c-erbB-2 in endometrial cancer, to study its correlation to established prognostic parameters and estrogen receptor (ER) and progesterone receptor (PR) status.

Methods: Immunohistochemical (IHC) analyses of ER, PR and c-erbB-2 were performed in 72 EC cases.

Results: We detected a positive staining with c erbB 2 in 18.1% of the cases and determined a statistically significant relation between c-erbB-2 and PR. We could not find a statistically significant relation between c-erbB-2 staining and ER. There was not a statistically significant difference between c-erbB-2 and histological grade. The highest level of c-erbB-2 was found in grade 2 cases. There was not any statistically significant relation between c-erbB-2 and menstrual status, myometrial invasion, lymph node status, stage and survival.

Conclusions: Although our study provides additional evidence of the potential prognostic role of c-erbB-2, further prospective and controlled studies are required to validate their clinical usefulness.

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Figures

Figure 1
Figure 1
Positive reaction for c-erbB-2 in endometrial adenocarcinoma (IHC×400).
Figure 2
Figure 2
Strong immunoreactivity for PR in the endometrial adenocarcinoma (IHC×200).
See this image and copyright information in PMC

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