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. 2010 Mar 30;220(1-2):131-5.
doi: 10.1016/j.jneuroim.2010.01.014. Epub 2010 Feb 18.

Production of immune-modulatory nonclassical molecules HLA-G and HLA-E by tumor infiltrating ameboid microglia/macrophages in glioblastomas: a role in innate immunity?

Leos Kren  1 , Katarina Muckova, Eva Lzicarova, Marek Sova, Vaclav Vybihal, Tomas Svoboda, Pavel Fadrus, Martin Smrcka, Ondrej Slaby, Radek Lakomy, Petr Vanhara, Zdenka Krenova, Jaroslav Michalek
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Production of immune-modulatory nonclassical molecules HLA-G and HLA-E by tumor infiltrating ameboid microglia/macrophages in glioblastomas: a role in innate immunity?

Leos Kren et al. J Neuroimmunol. .

Abstract

The possible role of immune-modulatory nonclassical molecules HLA-G and HLA-E in an anti-tumoral response and development of glioblastoma is not well characterized. In this study, we evaluated an expression of HLA-G and HLA-E by activated tumor infiltrating microglia/macrophages. We found production of HLA-G and HLA-E by tumor infiltrating activated microglia/macrophages in a majority of glioblastomas. We speculate that the expression of these molecules by activated microglia/CNS macrophages plays a role in the anti-tumoral immunity in the development of glioblastoma. Mechanisms of microglia-glioblastoma cell interactions with respect to the expression of these molecules deserves further study.

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