Comment
doi: 10.1073/pnas.1000323107.
Epub 2010 Feb 18.
mTORC1 activates SREBP-1c and uncouples lipogenesis from gluconeogenesis
Affiliations
- PMID: 20167806
- PMCID: PMC2840435
- DOI: 10.1073/pnas.1000323107
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Comment
mTORC1 activates SREBP-1c and uncouples lipogenesis from gluconeogenesis
Proc Natl Acad Sci U S A.
.
Erratum in
- Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7617
No abstract available
Conflict of interest statement
Author contributions: M.L. and D.M.S. wrote the paper.
The authors declare no conflict of interest.
Figures
The control of lipogenesis and gluconeogenesis by the insulin-signaling pathway. (A and B) Signaling events observed in the liver of (A) insulin-sensitive or (B) insulin-resistant models. (C) A hypothetical model suggesting how mTORC1 activation could drive both lipogenesis and gluconeogenesis in obese/insulin-resistant models. Glut4: glucose transporter-4; TSC1/2, tuberous sclerosis complex 1/2.
Comment on
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Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis.Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3441-6. doi: 10.1073/pnas.0914798107. Epub 2010 Feb 1. Proc Natl Acad Sci U S A. 2010. PMID: 20133650 Free PMC article.
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