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Review
. 2010 Apr-Jun;4(2):199-203.
doi: 10.4161/cam.4.2.10943. Epub 2010 Apr 14.

Snail: More than EMT

Yadi Wu  1 , Binhua P Zhou
Affiliations
Review

Snail: More than EMT

Yadi Wu et al. Cell Adh Migr. 2010 Apr-Jun.

Abstract

Snail has moved into the fast lane of development and cancer biology with the epithelial-mesenchymal transition (EMT) emerging as one of the hottest topics in medical science within the past few years. Snail not only acts primarily as a key inducer of EMT but also plays an important role in cell survival, immune regulation and stem cell biology. This review focuses on the regulation of Snail and discusses the EMT-dependent and -independent functions of Snail in development and disease. Understanding the regulation and functional roles of Snail will shed new light on the mechanism of tumor progression and the development of novel cancer therapies.

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Figures

Figure 1
Figure 1
Snail displays a broad spectrum of biological functions in the epithelial-mesenchymal transition (EMT), cell survival, immune regulation, tumor recurrence and stem cell biology.
See this image and copyright information in PMC

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