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. 2010 Feb 2:4:11-20.

Antiviral selection in the management of acute retinal necrosis

Patrick M K Tam  1 , Claire Y Hooper, Susan Lightman
Affiliations

Antiviral selection in the management of acute retinal necrosis

Patrick M K Tam et al. Clin Ophthalmol. .

Abstract

There is no consensus on the optimal antiviral regimen in the management of acute retinal necrosis, a disease caused by herpetic viruses with devastating consequences for the eye. The current gold standard is based on retrospective case series. Because the incidence of disease is low, few well-designed, randomized trials have evaluated treatment dosage and duration. Newer oral antiviral agents are emerging as alternatives to high-dose intravenous acyclovir, avoiding the need for inpatient intravenous treatment. Drug resistance is uncommon but may also be difficult to identify. Antiviral drugs have few side effects, but special attention needs to be paid to patients who have underlying renal disease, are pregnant or are immunocompromised.

Keywords: acute retinal necrosis; acyclovir; herpes; retinitis.

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References

    1. Sternberg P, Knox DK, Finkelstein D, Green WR, Murphy RP, Patz A. Acute retinal necrosis syndrome. Retina. 1982;2:145–151. - PubMed
    1. Holland GN. Standard diagnostic criteria for the acute retinal necrosis syndrome. Executive Committee of the American Uveitis Society. Am J Ophthalmol. 1994;117:663–667. - PubMed
    1. Urayama A, Yamada N, Susaki T, et al. Unilateral acute uveitis with periarteritis and detachment. J Clin Ophthalmol. 1971;25:607–619.
    1. Culbertson WW, Blumenkranz, Haines H, Gass DM, Mitchell KB, Norton EW. The acute retinal necrosis syndrome. Part 2: Histopathology and etiology. Ophthalmology. 1982;89:1317–1325. - PubMed
    1. Culbertson WW, Blumenkranz MS, Popose JS, et al. Varicella zoster virus is a cause of the acute retinal necrosis syndrome. Ophthalmology. 1986;93:559–569. - PubMed

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