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. 2010 Feb 19:5:3.
doi: 10.1186/1746-4358-5-3.

The effect of a controlled manipulation of maternal dietary fat intake on medium and long chain fatty acids in human breast milk in Saskatoon, Canada

Roseann Nasser #  1   2 , Alison M Stephen #  1   3 , Yeow K Goh #  4 , M Thomas Clandinin #  4
Affiliations

The effect of a controlled manipulation of maternal dietary fat intake on medium and long chain fatty acids in human breast milk in Saskatoon, Canada

Roseann Nasser et al. Int Breastfeed J. .

Abstract

Background: Few studies in recent years have demonstrated the effect of maternal diet on fatty acid composition of human milk.

Methods: Fourteen free-living lactating women participated in a cross-over dietary intervention study, consuming a low fat diet (17.6% of energy as fat, 14.4% of energy as protein, 68.0% of energy as carbohydrate) and a high fat diet (40.3% of energy as fat, 14.4% of energy as protein, 45.3% of energy as carbohydrate) each for periods of 4 days, in randomised order. Each mother was her own control. Mature milk samples were collected during each period and analysed for medium and long chain fatty acids.

Results: The concentration of medium chain fatty acids (MCFA), was 13.6% in breast milk for the low fat diet compared to 11.4% for the high fat (p < 0.05). Arachidonic acid (C20:4n-6) levels were significantly higher in breast milk when women consumed the low fat diet. Increased dietary intake of stearic acid (C18:0) and alpha-linolenic acid (C18:3n-3) on the high fat diet significantly increased proportions of these fatty acids in breast milk (p < 0.05) in 4 days.

Conclusions: Changing maternal dietary fat intake has a rapid response in terms of changes to fatty acids in breast milk.

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References

    1. Innis SM. Human milk: maternal dietary lipids and infant development. Proc Nutr Soc. 2007;66:397–404. doi: 10.1017/S0029665107005666. - DOI - PubMed
    1. Hachey DL, Thomas MR, Emken EA, Garza C, Brown-Booth L, Adlof RO, Klein PD. Human lactation: maternal transfer to dietary triglycerides labeled with stable isotopes. J Lipid Res. 1987;28:1185–1192. - PubMed
    1. Emken EA, Adlof RO, Hachey DL, Garza C, Thomas MR, Brown-Booth L. Incorporation of deuterium-labeled fatty acids into human milk, plasma and lipoprotein phospholipids and cholesterol esters. J Lipid Res. 1989;30:395–402. - PubMed
    1. Thompson BJ, Smith S. Biosynthesis of fatty acids by lactating human breast epithelial cells: an evaluation of the contribution to the overall composition of human milk fat. Pediatr Res. 1985;19:139–143. doi: 10.1203/00006450-198501000-00036. - DOI - PubMed
    1. Harzer G, Dieterich I, Haug M. Effects of the diet on the composition of human milk. Ann Nutr Metab. 1984;28:231–239. doi: 10.1159/000176809. - DOI - PubMed

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