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Review
. 2010 Mar 1;76(3 Suppl):S116-22.
doi: 10.1016/j.ijrobp.2009.02.090.

Radiation dose-volume effects of the urinary bladder

Akila N Viswanathan  1 , Ellen D Yorke, Lawrence B Marks, Patricia J Eifel, William U Shipley
Affiliations
Review

Radiation dose-volume effects of the urinary bladder

Akila N Viswanathan et al. Int J Radiat Oncol Biol Phys. .

Abstract

An in-depth overview of the normal-tissue radiation tolerance of the urinary bladder is presented. The most informative studies consider whole-organ irradiation. The data on partial-organ/nonuniform irradiation are suspect because the bladder motion is not accounted for, and many studies lack long enough follow-up data. Future studies are needed.

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Conflict of interest statement

Conflict of interest: none

Figures

Fig. 1
Fig. 1
Incidence of Radiation Therapy Oncology Group Grade 3 or greater late bladder toxicity in relation to average dose (squares) or linear-quadratic model equivalent dose (triangles) in 2-Gy fractions (assuming α/β = 6 Gy) for studies treating whole bladder only (listed in Table 1 and reviewed by Marks, et al. [1]). Letter in each square denotes data source: publication specified in key as first author followed by superscript reference number. Note, Quilty and Duncan (20) had four dose groups. Number of patients italicized inside each square. No significant correlation was found between complication rate and either dose or equivalent dose. (Courtesy of E.D. Yorke.)
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