Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010 Mar 1;76(3 Suppl):S140-4.
doi: 10.1016/j.ijrobp.2009.08.077.

Imaging for assessment of radiation-induced normal tissue effects

Robert Jeraj  1 , Yue Cao, Randall K Ten Haken, Carol Hahn, Lawrence Marks
Affiliations
Review

Imaging for assessment of radiation-induced normal tissue effects

Robert Jeraj et al. Int J Radiat Oncol Biol Phys. .

Abstract

Imaging can provide quantitative assessment of radiation-induced normal tissue effects. Identifying an early sign of normal tissue damage with imaging would have the potential to predict organ dysfunction, thereby allowing reoptimization of treatment strategies based on individual patients' risks and benefits. Early detection with noninvasive imaging may enable interventions to mitigate therapy-associated injury before its clinical manifestation. Furthermore, successive imaging may provide an objective assessment of the impact of such mitigation therapies. However, many problems make application of imaging to normal tissue assessment challenging, and further work is required to establish imaging biomarkers as surrogate endpoints of clinical outcome. The performance of clinical trials in which normal tissue injury is a clearly defined endpoint would greatly aid in realization of these goals.

PubMed Disclaimer

Conflict of interest statement

Conflict of interest: No conflicts of interest noted.

Figures

Figure 1
Figure 1
Relation between normal tissue effects and their clinical manifestation, and role of imaging to assess the effects.
See this image and copyright information in PMC

References

    1. Rodemann HP, Blaese MA. Responses of normal cells to ionizing radiation. Semin Radiat Oncol. 2007;17:81–88. - PubMed
    1. Marks LB. Oncology. Vol. 8. Williston Park, N.Y.: 1994. The pulmonary effects of thoracic irradiation; pp. 89–106. discussion 100, 103. - PubMed
    1. Dawson LA, Ten Haken RK. Partial volume tolerance of the liver to radiation. Semin Radiat Oncol. 2005;15:279–283. - PubMed
    1. Lawrence TS, Robertson JM, Anscher MS, et al. Hepatic toxicity resulting from cancer treatment. Int J Radiat Oncol Biol Phys. 1995;31:1237–1248. - PubMed
    1. Vos MJ, Hoekstra OS, Barkhof F, et al. Thallium-201 single-photon emission computed tomography as an early predictor of outcome in recurrent glioma. Journal of Clinical Oncology. 2003;21:3559–3565. - PubMed

MeSH terms