Review
doi: 10.1016/j.ijrobp.2009.07.1753.
Radiation dose-volume effects of optic nerves and chiasm
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- PMID: 20171514
- DOI: 10.1016/j.ijrobp.2009.07.1753
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Review
Radiation dose-volume effects of optic nerves and chiasm
Int J Radiat Oncol Biol Phys.
.
Abstract
Publications relating radiation toxicity of the optic nerves and chiasm to quantitative dose and dose-volume measures were reviewed. Few studies have adequate data for dose-volume outcome modeling. The risk of toxicity increased markedly at doses >60 Gy at approximately 1.8 Gy/fraction and at >12 Gy for single-fraction radiosurgery. The evidence is strong that radiation tolerance is increased with a reduction in the dose per fraction. Models of threshold tolerance were examined.
Copyright 2010 Elsevier Inc. All rights reserved.
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