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Review
. 2010 Mar 1;76(3 Suppl):S28-35.
doi: 10.1016/j.ijrobp.2009.07.1753.

Radiation dose-volume effects of optic nerves and chiasm

Charles Mayo  1 , Mary K Martel, Lawrence B Marks, John Flickinger, Jiho Nam, John Kirkpatrick
Affiliations
Review

Radiation dose-volume effects of optic nerves and chiasm

Charles Mayo et al. Int J Radiat Oncol Biol Phys. .

Abstract

Publications relating radiation toxicity of the optic nerves and chiasm to quantitative dose and dose-volume measures were reviewed. Few studies have adequate data for dose-volume outcome modeling. The risk of toxicity increased markedly at doses >60 Gy at approximately 1.8 Gy/fraction and at >12 Gy for single-fraction radiosurgery. The evidence is strong that radiation tolerance is increased with a reduction in the dose per fraction. Models of threshold tolerance were examined.

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