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Review
. 2010 Mar 1;76(3 Suppl):S77-85.
doi: 10.1016/j.ijrobp.2009.04.093.

Radiation dose-volume effects in the heart

Giovanna Gagliardi  1 , Louis S Constine, Vitali Moiseenko, Candace Correa, Lori J Pierce, Aaron M Allen, Lawrence B Marks
Affiliations
Review

Radiation dose-volume effects in the heart

Giovanna Gagliardi et al. Int J Radiat Oncol Biol Phys. .

Abstract

The literature is reviewed to identify the main clinical and dose-volume predictors for acute and late radiation-induced heart disease. A clear quantitative dose and/or volume dependence for most cardiac toxicity has not yet been shown, primarily because of the scarcity of the data. Several clinical factors, such as age, comorbidities and doxorubicin use, appear to increase the risk of injury. The existing dose-volume data is presented, as well as suggestions for future investigations to better define radiation-induced cardiac injury.

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Comment in

  • In Regard to Gagliardi et al.
    Chang JH, Cha MJ. Chang JH, et al. Int J Radiat Oncol Biol Phys. 2019 May 1;104(1):219-220. doi: 10.1016/j.ijrobp.2018.12.030. Int J Radiat Oncol Biol Phys. 2019. PMID: 30967227 No abstract available.