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. 2010 May;118(1-3):62-8.
doi: 10.1016/j.schres.2010.01.019. Epub 2010 Feb 19.

Do inter-regional gray-matter volumetric correlations reflect altered functional connectivity in high-risk offspring of schizophrenia patients?

Tejas S Bhojraj  1 , Konasale M Prasad, Shaun M Eack, Alan N Francis, Debra M Montrose, Matcheri S Keshavan
Affiliations

Do inter-regional gray-matter volumetric correlations reflect altered functional connectivity in high-risk offspring of schizophrenia patients?

Tejas S Bhojraj et al. Schizophr Res. 2010 May.

Abstract

Background: Schizophrenia patients and their relatives show aberrant functional connectivity in default network regions (DRs) such as the medial prefrontal, lateral temporal, cingulate and inferior parietal cortices and executive regions such as the dorsolateral prefrontal cortex (DLPFC). Gray-matter volumetric alterations may be related to these functional connectivity deficits. Also, gray-matter volume inter-regional correlations may reflect altered inter-regional functional connectivity.

Aims: To examine our prediction of alterations of gray-matter volumes and inter-regional volume correlations for DRs and the DLPFC in offspring of schizophrenia patients (OS).

Methods: We assessed 64 adolescent and young adult OS and 80 healthy controls (HC) using T1-MRI. Regional gray-matter volumes and inter-regional volume correlations between the DRs and between the DLPFC and DRs on each side were compared across groups.

Results: Compared to HC, OS had reductions in several DRs and the DLPFC after controlling age, gender, and intra-cranial volume, and correcting for multiple comparisons. OS had stronger (more positive) gray-matter volume inter-correlations between DRs and between DRs and the DLPFC.

Conclusions: Volumetric deficits in the default network and in the DLPFC may be related to familial diathesis in schizophrenia and to functional connectivity abnormalities in those at familial risk. Increased inter-correlations between DRs and between DR and DLPFC gray-matter volumes may serve as surrogate indices of abnormal functional connectivity.

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Conflict of interest statement

Disclosure/Conflict of Interest Statement

This research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Inter-regional correlations for each group for each pair of regions are depicted. The X-axis denotes each pair of inter correlated regions. Inter-regional correlations are plotted on the Y-axis with the height of the bars equaling the magnitude of the inter-regional correlation for that pair of regions. Red and blue bars denote inter-regional correlations for OS and HC respectively. While the correlations in OS were significant, none of the inter-correlations for HC reached significance. All inter-regional correlations except that for the L ACC- L MPFC region-pair were significant at p < 0.05 (two tailed) in OS subjects. Inter-correlations for none of the region-pairs in HC subjects reached significance. Difference of r tests comparing the inter-regional correlations between OS and HC were performed and the two tailed p values for these across group difference for inter-regional correlations are provided in parentheses on the X-axis. MPFC = medial prefrontal cortex, ACC = anterior cingulate cortex, PCC = posterior cingulate cortex, IPL= inferior parietal lobule and DLPFC = dorso lateral prefrontal cortex. LT= Lateral temporal cortex
See this image and copyright information in PMC

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