Review
[Vasculotropin: a new angiogenic growth factor]
[Article in
French]
Affiliations
- PMID: 2017341
Item in Clipboard
Review
[Vasculotropin: a new angiogenic growth factor]
[Article in
French]
Pathol Biol (Paris).
1991 Feb.
Abstract
A new growth factor, provisionally named vasculotropin (VAS), with a unique specificity for vascular endothelial cells has been purified to homogeneity. VAS is a 45 kDa glycosylated homodimeric protein. Cloning of the VAS gene has evidenced a sequence homology with A and B chains of Platelet-Derived Growth Factor. The receptor on vascular endothelial cells has been shown to be a 180 kDa protein. A 110 kDa receptor has been found on cells that do not respond to the mitogenic effect of vasculotropin, such as lens epithelial cells or corneal endothelial cells.
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