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Review
. 1991 Feb;39(2):153-6.

[Vasculotropin: a new angiogenic growth factor]

[Article in French]
H Moukadiri  1 , C Favard, V Praloran, J Plouet
Affiliations
  • PMID: 2017341
Review

[Vasculotropin: a new angiogenic growth factor]

[Article in French]
H Moukadiri et al. Pathol Biol (Paris). 1991 Feb.

Abstract

A new growth factor, provisionally named vasculotropin (VAS), with a unique specificity for vascular endothelial cells has been purified to homogeneity. VAS is a 45 kDa glycosylated homodimeric protein. Cloning of the VAS gene has evidenced a sequence homology with A and B chains of Platelet-Derived Growth Factor. The receptor on vascular endothelial cells has been shown to be a 180 kDa protein. A 110 kDa receptor has been found on cells that do not respond to the mitogenic effect of vasculotropin, such as lens epithelial cells or corneal endothelial cells.

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