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. 2010 Jan;52(1):21-7.
doi: 10.4103/0019-5545.58891.

What is schizophrenia: A neurodevelopmental or neurodegenerative disorder or a combination of both? A critical analysis

Swapnil Gupta  1 , Parmanand Kulhara
Affiliations

What is schizophrenia: A neurodevelopmental or neurodegenerative disorder or a combination of both? A critical analysis

Swapnil Gupta et al. Indian J Psychiatry. 2010 Jan.

Abstract

The etiology of schizophrenia has been the focus of intensive research for a long time. Perspectives have changed drastically with the development of new investigative techniques. Clinical observations made by Kraepelin, Clouston, Bender, and Watt are now being complemented by neuroimaging and genetic studies to prove the neurodevelopmental hypothesis. At the same time, neuropathological and longitudinal studies of schizophrenia often support a neurodegenerative hypothesis. To provide a theoretical basis to the available evidence, another hypothesis called the progressive neurodevelopmental model has also emerged. This review presents some key evidence supporting each of these theories followed by a critical analysis of each.

Keywords: Schizophrenia; neurodegeneration; neurodevelopmental.

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Conflict of interest statement

Conflict of Interest: None declared

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References

    1. Bender L. Childhood schizophrenia: Clinical study of 100 schizophrenia children. Am J Orthopsychiatry. 1947;17:40–56. - PubMed
    1. Watt NF. Patterns of childhood social development in adult schizophrenics. Arch Gen Psychiatry. 1978;35:106–5. - PubMed
    1. Clouston T, Murray MR, Bramon E. In Developmental model of schizophrenia. In: Sadock BJ, Sadock VA, editors. Comprehensive Textbook of Psychiatry. 8th ed. Philadelphia: Lippincot Williams and Wilkins; 2005. p. 1381. Cited by.
    1. Southard EF. On the topographical distribution of cortical lesions and anomalies in dementia praecox, with some account of their functional significance. American J Insanity. 1915;71:603–71.
    1. Jones PB, Rantakallio P, Hartikainen AL, Isohanni M, Sipila P. Schizophrenia as a long term outcome of pregnancy, delivery, and perinatal complications: A 28 year follow up of the North Finland general population birth cohort. Am J Psychiatry. 1998;155:355–64. - PubMed