Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Aug;52(8):729-33.
doi: 10.1007/s00234-010-0653-1. Epub 2010 Feb 20.

Diffusion tensor tract-specific analysis of the uncinate fasciculus in patients with amyotrophic lateral sclerosis

Kanako Sato  1 , Shigeki Aoki, Nobue K Iwata, Yoshitaka Masutani, Takeyuki Watadani, Yasuhiro Nakata, Mariko Yoshida, Yasuo Terao, Osamu Abe, Kuni Ohtomo, Shoji Tsuji
Affiliations

Diffusion tensor tract-specific analysis of the uncinate fasciculus in patients with amyotrophic lateral sclerosis

Kanako Sato et al. Neuroradiology. 2010 Aug.

Abstract

Introduction: The uncinate fasciculus (UF) consists of core fibers connecting the frontal and temporal lobes and is considered to be related to cognitive/behavioral function. Using diffusion tensor tractography, we quantitatively evaluated changes in fractional anisotropy (FA) and the apparent diffusion coefficient (ADC) of the UF by tract-specific analysis to evaluate the damage of the UF in patients with amyotrophic lateral sclerosis (ALS).

Methods: We obtained diffusion tensor images of 15 patients with ALS and 9 age-matched volunteers.

Results: Patients with ALS showed significantly lower mean FA (P = 0.029) compared with controls. No significant difference was seen in mean ADC.

Conclusion: The results suggest that damage of the UF in patients with ALS can be quantitatively evaluated with FA.

PubMed Disclaimer

References

    1. Neuroradiology. 2008 Jul;50(7):605-11 - PubMed
    1. Neuropsychology. 2004 Oct;18(4):629-637 - PubMed
    1. Biophys J. 1994 Jan;66(1):259-67 - PubMed
    1. Neuropsychologia. 2002;40(9):1608-21 - PubMed
    1. J Neurol Neurosurg Psychiatry. 1998 Dec;65(6):881-9 - PubMed

MeSH terms