Diffusion tensor tract-specific analysis of the uncinate fasciculus in patients with amyotrophic lateral sclerosis
- PMID: 20174788
- DOI: 10.1007/s00234-010-0653-1
Diffusion tensor tract-specific analysis of the uncinate fasciculus in patients with amyotrophic lateral sclerosis
Abstract
Introduction: The uncinate fasciculus (UF) consists of core fibers connecting the frontal and temporal lobes and is considered to be related to cognitive/behavioral function. Using diffusion tensor tractography, we quantitatively evaluated changes in fractional anisotropy (FA) and the apparent diffusion coefficient (ADC) of the UF by tract-specific analysis to evaluate the damage of the UF in patients with amyotrophic lateral sclerosis (ALS).
Methods: We obtained diffusion tensor images of 15 patients with ALS and 9 age-matched volunteers.
Results: Patients with ALS showed significantly lower mean FA (P = 0.029) compared with controls. No significant difference was seen in mean ADC.
Conclusion: The results suggest that damage of the UF in patients with ALS can be quantitatively evaluated with FA.
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