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Review
. 2010 Feb;39(1):61-78.
doi: 10.1007/s12160-010-9165-9.

Posttraumatic stress disorder, cardiovascular, and metabolic disease: a review of the evidence

Eric A Dedert  1 , Patrick S Calhoun, Lana L Watkins, Andrew Sherwood, Jean C Beckham
Affiliations
Review

Posttraumatic stress disorder, cardiovascular, and metabolic disease: a review of the evidence

Eric A Dedert et al. Ann Behav Med. 2010 Feb.

Abstract

Background: Posttraumatic stress disorder (PTSD) is a significant risk factor for cardiovascular and metabolic disease.

Purpose: The purpose of the current review is to evaluate the evidence suggesting that PTSD increases cardiovascular and metabolic risk factors, and to identify possible biomarkers and psychosocial characteristics and behavioral variables that are associated with these outcomes.

Methods: A systematic literature search in the period of 2002-2009 for PTSD, cardiovascular disease, and metabolic disease was conducted.

Results: The literature search yielded 78 studies on PTSD and cardiovascular/metabolic disease and biomarkers.

Conclusions: Although the available literature suggests an association of PTSD with cardiovascular disease and biomarkers, further research must consider potential confounds, incorporate longitudinal designs, and conduct careful PTSD assessments in diverse samples to address gaps in the research literature. Research on metabolic disease and biomarkers suggests an association with PTSD, but has not progressed as far as the cardiovascular research.

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Figures

Figure 1
Figure 1. Model of PTSD and Cardiovascular/Metabolic Disease
Model of the influences of traumatic stress risk, PTSD, psychological states, and health behavior on pre-clinical disease markers. It is proposed that pre-clinical disease biomarkers then progress to cardiovascular/metabolic disease through autonomic dysregulation, endothelial dysfunction, metabolic syndrome, and insulin resistance. This figure modified from Schnurr & Jankowski (8).
See this image and copyright information in PMC

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