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. 2010 Mar 19;12(6):1172-5.
doi: 10.1021/ol902907r.

Diverse DNA-cleaving capacities of the jadomycins through precursor-directed biosynthesis

Krista M Cottreau  1 , Colin Spencer, Jason R Wentzell, Cathy L Graham, Charles N Borissow, David L Jakeman, Sherri A McFarland
Affiliations

Diverse DNA-cleaving capacities of the jadomycins through precursor-directed biosynthesis

Krista M Cottreau et al. Org Lett. .

Abstract

Gel mobility assays were used to establish that some members of the jadomycin family of natural products act as DNA cleaving agents. Moreover, it was found that subtle structural changes generated through the use of precursor-directed biosynthesis lead to marked effects on the DNA-damaging properties of these glycosylated polyketide-derived natural products.

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