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Review
. 2010 Feb;267(2):139-55.
doi: 10.1111/j.1365-2796.2009.02202.x.

The genetics of ischaemic stroke

M Matarin  1 , A Singleton, J Hardy, J Meschia
Affiliations
Review

The genetics of ischaemic stroke

M Matarin et al. J Intern Med. 2010 Feb.

Abstract

In this review, we discuss the genetic factors in both the aetiology and treatment of ischaemic stroke. We discuss candidate gene association studies, family linkage studies and the more recent whole genome association studies and whole genome expression studies. We also briefly discuss genetic testing for stroke risk and genetic analysis of treatment complications.

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Conflict of interest statement

Conflict of interest statement: No conflict of interest was declared.

Figures

Figure 1
Figure 1
Potential pharmacogenetic considerations in optimizing stroke prevention. Genetic testing could be used to stratify risk of future large vessel atherosclerotic stroke or cardioembolic stroke. Genetic testing could also be used to help safely initiate warfarin anticoagulation or identify individuals not likely to respond to clopidogrel. It could also be used to identify individuals at risk of myositis associated with statin use.
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