Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Nov 1;4(6):775-784.
doi: 10.2217/fnl.09.55.

Development of histone deacetylase inhibitors as therapeutics for neurological disease

Joel M Gottesfeld  1 , Massimo Pandolfo
Affiliations

Development of histone deacetylase inhibitors as therapeutics for neurological disease

Joel M Gottesfeld et al. Future Neurol. .

Abstract

Postsynthetic modifications of histone and other chromosomal proteins by reversible acetylation and/or methylation regulate many aspects of chromatin dynamics, such as transcription, replication and DNA repair. Aberrant modification states are associated with several neurological and neuromotor diseases. Thus, small molecules that inhibit or activate the enzymes responsible for these chromatin modifications have received considerable attention as potential human therapeutics. This paper summarizes the current state of development of histone deacetylase inhibitors in a variety of neurological diseases.

PubMed Disclaimer

References

Bibliography

    1. Luger K, Mader AW, Richmond RK, Sargent DF, Richmond TJ. Crystal structure of the nucleosome core particle at 2.8 A resolution. Nature. 1997;389:251–260. - PubMed

    2. ▪▪ Describes the structure of the nucleosome at atomic resolution and provides details for how nucleosomes might contribute to gene regulation.

    1. Hayes JJ, Hansen JC. Nucleosomes and the chromatin fiber. Curr Opin Genet Dev. 2001;11:124–129. - PubMed
    1. Shogren-Knaak M, Ishii H, Sun JM, Pazin MJ, Davie JR, Peterson CL. Histone H4-K16 acetylation controls chromatin structure and protein interactions. Science. 2006;311:844–847. - PubMed

    2. ▪ Demonstrates that a particular histone modification can have a profound influence on chromatin structure and possibly gene expression.

    1. Jacobs SA, Khorasanizadeh S. Structure of HP1 chromodomain bound to a lysine 9-methylated histone H3 tail. Science. 2002;295:2080–2083. - PubMed
    1. Taverna SD, Li H, Ruthenburg AJ, Allis CD, Patel DJ. How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers. Nat Rev Struct Mol Biol. 2007;14:1025–1040. - PMC - PubMed

Website

    1. Clinical trials registry. www.clinicaltrials.gov.

LinkOut - more resources