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. 2009 Jan;71(1):62-6.
doi: 10.4103/0250-474X.51963.

Synthesis and Biological Evaluation of beta-Aroylpropionic acid based 1,3,4-Oxadiazoles

A Husain  1 , Priyanka Ahuja, Sarafroz
Affiliations

Synthesis and Biological Evaluation of beta-Aroylpropionic acid based 1,3,4-Oxadiazoles

A Husain et al. Indian J Pharm Sci. 2009 Jan.

Abstract

In the present investigation, two new series, 1-(4-benzylphenyl)-3-(5-substituted-1,3,4-oxadiazol-2-yl)-1-propanone and 1-(4-ethylphenyl)-3-(5-substituted-1,3,4-oxadiazol-2-yl)-1-propanone from beta-(4-benzylbenzoyl)propionic acid and beta-(4-ethylbenzoyl)propionic acid, respectively, were synthesized and tested for antiinflammatory, analgesic, lipid peroxidation, ulcerogenic and antibacterial actions. A fair number of compounds were found to have good antiinflammatory activity in carrageenan-induced rat paw edema test, while a few compounds showed significant antibacterial activity. The newly synthesized compounds showed very low ulcerogenic action.

Keywords: Oxadiazoles; analgesic; antibacterial; antiinflammatory; aroylpropionic acid.

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Figures

Scheme 1
Scheme 1
Synthetic route for the preparation of 1,3,4-oxadiazoles, 5a-l, 6a-e
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References

    1. Franski R. Biological activities of the compounds bearing 1,3,4-oxa(thia)diazole ring. Asian J Chem. 2005;17:2063–75.
    1. Omar FA, Mahfouz NM, Rahman MA. Design, synthesis and antiinflammatory activity of some 1,3,4-oxadiazole derivatives. Eur J Med Chem. 1996;31:819–25. - PubMed
    1. Narayana B, Vijayaraj KK, Ashalatha BV, Kumari NS. Synthesis of some new 2-(6-methoxy-2-naphthyl)-5-aryl-1,3,4-oxadiazoles as possible non-steroidal antiinflammatory and analgesic agents. Arch Pharm (Weinheim) 2005;338:373–7. - PubMed
    1. Kamble RR, Sudha BS. Synthesis and Pharmacological Screening of 5-methyl-3-[p-(6'-aryl-2'-thioxo-1',2',5',6'-tetrahydropyrimidin-4'-yl)-phenyl]-3H-2-oxo-Δ4-1,3,4-oxadiazoles. Indian J Pharm Sci. 2006;68:249–53.
    1. Bezerra NMM, De Oliveira SP, Srivastava RM, Da Silva JR. Synthesis of 3-aryl-5-decapentyl-1,2,4-oxadiazoles possessing antiinflammatory and antitumor properties. Farmaco. 2005;60:955–60. - PubMed

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