Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Feb;41(1):47-8.
doi: 10.4103/0253-7613.48884.

Emergence of pristinamycin resistance in India

Shyam Sunder Keshari  1 , Arun Kumar Kapoor, Nira Kastury, Dharmendra Kumar Singh, Anudita Bhargava
Affiliations

Emergence of pristinamycin resistance in India

Shyam Sunder Keshari et al. Indian J Pharmacol. 2009 Feb.

Abstract

Quinupristin and dalfopristin combination has been advocated as a drug of choice for multi-drug resistant (MDR) gram-positive cocci (GPC). We are reporting two cases of neonatal septicemia, caused by the methicillin resistant Staphylococcus aureus (MRSA), showing primary in vitro pristinamycin resistance. The Minimum inhibitory concentrations (MIC) for pristinamycin in these two cases were 30 mug and 25 mug, respectively. Universal advocacy of pristinamycin for the therapy of MDR GPC infections should be re-evaluated.

Keywords: Dalfopristin/quinupristin; pristinamycin resistance; staphylococcus.

PubMed Disclaimer

References

    1. Chamber HF. Antimicrobial agents: Protein synthesis inhibitors and miscellaneous antibacterial agents. In: Burton LL, Lazo JS, Parker KL, editors. Goodman and Gillman.s the pharmacological basis of therapeutics. 11th ed. New York: McGraw-Hill; 2006. pp. 1173–202.
    1. Haroche J, Morvan A, Davi M, Allignet J, Bimet F, El Solh N. Clonal diversity among streptogramin A: resistant Staphylococcus aureus isolates collected in French hospitals. J Clin Microbiol. 2003;41:586–91. - PMC - PubMed
    1. El Solh N, Allignet J. Staphylococcal resistance to streptogramins and related antibiotics. Drug Resist Updates. 1998;1:169–75. - PubMed
    1. Allignet J, Aubert S, Morvan A, El Solh N. Distribution of genes encoding resistance to streptogramin A and related compounds among staphylococcal resistant to these antibiotics. Antimicrob Agents Chemother. 1996;40:2523–8. - PMC - PubMed
    1. Weisblum B. Resistance to the macrolide –lincosamide –streptogramin antibiotics. In: Fischetti VA, editor. Gram-positive pathogens. Washington, DC: ASM Press; 2000. pp. 694–710.